abcg5 gene responses to treadmill running with or without administration of pistachio atlantica in female rats

objective(s): abc transporters comprise a large family of transmembrane proteins that use the energy provided by atp hydrolysis to translocate a variety of substrates across biological membranes. all members of the human abcg subfamily, except for abcg2, are cholesterol-transporter. the aim of this study was to determine the liver, the small intestine and kidney abcg5 relative gene expression in response to treadmill-running training in female rats. materials and methods: twenty wistar rats (6-8 weeks old and 125-135 g weight) were used. animals were randomly assigned to saline-control (sc), saline-training (st), and baneh-control (bc), and baneh-training (bt) groups. training groups did the exercise on a motor-driven treadmill at 25 m/min (0% grade) for 60 min/day for eight weeks (5 days/week). rats were fed orally, with baneh extraction and saline for six weeks. the two-way anova was employed for statistical analysis.  abcg5 relative gene expression was detected by real-time pcr method. results:the current findings indicate that the baneh-treated tissues had significantly lower levels of abcg5 gene expression in the liver, small intestine, and kidneys (p< 0.001, p< 0.003, p< 0.001, respectively), when compared with saline-treated tissues. however, a higher level of gene expression was observed in exercise groups. a lower level of hdl-c but not triglyceride (tg) and total cholesterol (tc) levels were found in baneh-treated animals at rest. conclusion: exercise training increases abcg5 relative gene expression in the liver, small intestine and kidney tissues; therefore exercise training may adjust the reduction of abcg5 relative gene expression in baneh-training group.